If you prefer to use Chrome’s or IE’s own dev tools to do client-side debugging, the recent update to Visual Studio 2017 RC introduced a setting to disable the IE and Chrome script debugger (this will also prevent Chrome/IE from closing after a debugging session ends). Go to Tools -> Options -> Debugging -> General and turn off the setting Enable JavaScript Debugging for ASP.NET (Chrome and IE).
This needs to be done as well sometimes:
Tools > Options > Projects and Solutions > Web Projects, uncheck “Stop debugger when browser window is closed”
Source: Client-side debugging of ASP.NET projects in Google Chrome | .NET Web Development and Tools Blog